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重要文件

P3494

Sigma-Aldrich

克拉维酸钾

from Streptomyces clavuligerus

同義詞:

棒酸钾

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About This Item

經驗公式(希爾表示法):
C8H8NO5K
CAS號碼:
分子量::
237.25
EC號碼:
MDL號碼:
分類程式碼代碼:
51101500
PubChem物質ID:

生物源

Streptomyces clavuligerus

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

[K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(\O2)=C\CO

InChI

1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1

InChI 密鑰

ABVRVIZBZKUTMK-JSYANWSFSA-M

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生化/生理作用

β-内酰胺酶抑制剂,通常加入阿莫西林以提高其功效。
In combination with penicillin group antibiotics to inhibit specific (group 2) β-penicillinases and cephalosporinases.

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象形圖

FlameHealth hazard

訊號詞

Danger

危險分類

Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1

安全危害

儲存類別代碼

4.2 - Pyrophoric and self-heating hazardous materials

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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Gustavo Jesus Vazquez-Zapien et al.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 60(1), 189-194 (2019-07-03)
Kidney diseases are a global public health problem. Despite significant advances in the understanding of renal failure (RF) and replacement therapies, this condition carries a series of complications and the life's quality of patients decreases. Differentiation capability of stem cells
Winfried V Kern et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(9), 1149-1156 (2013-01-30)
This double-blind, multicenter trial compared the efficacy and safety of a single daily oral dose of moxifloxacin with oral combination therapy in low-risk febrile neutropenic patients with cancer. Inclusion criteria were cancer, febrile neutropenia, low risk of complications as predicted
Jung-Whan Chon et al.
International journal of food microbiology, 165(1), 7-10 (2013-05-21)
The presence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) in raw poultry is one of the most common factors that interfere with the isolation of Campylobacter by cefoperazone-based selective agar. The performance of modified charcoal-cefoperazone-deoxycholate agar (mCCDA) was improved
Thomas Kwong et al.
Antimicrobial agents and chemotherapy, 56(9), 4845-4855 (2012-07-04)
Streptomyces clavuligerus produces a collection of five clavam metabolites, including the clinically important β-lactamase inhibitor clavulanic acid, as well as four structurally related metabolites called 5S clavams. The paralogue gene cluster of S. clavuligerus is one of three clusters of
Krisztina M Papp-Wallace et al.
Antimicrobial agents and chemotherapy, 56(8), 4428-4438 (2012-06-13)
β-Lactamases are important antibiotic resistance determinants expressed by bacteria. By studying the mechanistic properties of β-lactamases, we can identify opportunities to circumvent resistance through the design of novel inhibitors. Comparative amino acid sequence analysis of class A β-lactamases reveals that

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