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P1223

Sigma-Aldrich

二油酰基 L-α-磷脂酰乙醇胺

≥99% (GC), ≥98% (TLC), lyophilized powder

同義詞:

1,2-二油酰基-sn-丙三基-3-磷酸乙醇胺, 3-sn-磷脂酰乙醇胺, 1,2-二油酰, L-β,γ-二油酰-α-脑磷脂, DOPE, PE(18:1(9Z)/18:1(9Z)), 二油酰磷脂酰乙醇胺

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About This Item

經驗公式(希爾表示法):
C41H78NO8P
CAS號碼:
分子量::
744.03
Beilstein:
1718431
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.25

生物源

synthetic

品質等級

化驗

≥98% (TLC)
≥99% (GC)

形狀

lyophilized powder

官能基

phospholipid

脂質類型

phosphoglycerides

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-

InChI 密鑰

MWRBNPKJOOWZPW-CLFAGFIQSA-N

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應用

1,2-二油酰-sn-甘油-3-磷酸乙醇胺(DOPE)可与N-[1-(2,3-二油酰氧基)丙基] -N,N,N-三甲基甲基硫酸铵(DOTAP)形成异质脂质体而作为治疗剂的运载工具
与 DC-胆固醇(可用于有效转染几种哺乳动物细胞系)形成脂质体。

包裝

在氩气下包装。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Jiao Wang et al.
Scientific reports, 8(1), 10795-10795 (2018-07-19)
P4-ATPases are a subfamily of P-type ATPases that flip phospholipids across membranes to generate lipid asymmetry, a property vital to many cellular processes. Mutations in several P4-ATPases have been linked to severe neurodegenerative and metabolic disorders. Most P4-ATPases associate with
Juliette Fedry et al.
PLoS biology, 16(8), e2006357-e2006357 (2018-08-14)
HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host membrane. However, the
Guangsheng Du et al.
Journal of controlled release : official journal of the Controlled Release Society, 266, 109-118 (2017-09-26)
In this study, we investigated the potential of intradermal delivery of nanoparticulate vaccines to modulate the immune response of protein antigen using hollow microneedles. Four types of nanoparticles covering a broad range of physiochemical parameters, namely poly (lactic-co-glycolic) (PLGA) nanoparticles
Ernest Y Lee et al.
Nature communications, 10(1), 1012-1012 (2019-03-06)
Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune cells and exacerbate autoimmune diseases. The rules governing
Tatjana Michel et al.
Molecular therapy. Nucleic acids, 8, 459-468 (2017-09-18)
Synthetically modified mRNA is a unique bioactive agent, ideal for use in therapeutic applications, such as cancer vaccination or treatment of single-gene disorders. In order to facilitate mRNA transfections for future therapeutic applications, there is a need for the delivery

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