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O3514

Sigma-Aldrich

Bovine Osteopontin

from bovine milk, powder, suitable for cell culture

同義詞:

Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

product name

Osteopontin from bovine milk, lyophilized powder

生物源

bovine milk

品質等級

無菌

sterile

形狀

lyophilized powder

分子量

~60 kDa

包裝

pkg of 50 μg

技術

cell culture | mammalian: suitable

UniProt登錄號

運輸包裝

ambient

儲存溫度

−20°C

基因資訊

一般說明

Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.

生化/生理作用

A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.
Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

分析報告

The biological activity is measured by its ability to mediate 293 cell adhesion.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (1999)
Molecular analysis of the Bacillus subtilis bacteriophage SPP1 region encompassing genes 1 to 6: The products of gene 1 and gene 2 are required for pac cleavage.
Chai S, et al.
Journal of Molecular Biology, 224(1), 87-102 (1992)
Milk Proteins: From Expression to Food (2014)
Milk and Milk Products in Human Nutrition (2011)
D D Hu et al.
The Journal of biological chemistry, 270(44), 26232-26238 (1995-11-03)
Osteopontin (OPN) is an extracellular matrix protein that binds to integrin alpha v beta 3. Here we demonstrate that two other integrins, alpha v beta 1 and alpha v beta 5, are also receptors for OPN. Human embryonic kidney 293

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