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Merck
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O3011

Sigma-Aldrich

Oxiracetam

同義詞:

4-Hydroxy-2-oxopyrrolidine-N-acetamide

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About This Item

經驗公式(希爾表示法):
C6H10N2O3
CAS號碼:
分子量::
158.16
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

儲存溫度

2-8°C

SMILES 字串

NC(=O)CN1CC(O)CC1=O

InChI

1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)

InChI 密鑰

IHLAQQPQKRMGSS-UHFFFAOYSA-N

生化/生理作用

Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Y Lu et al.
Brain research, 768(1-2), 197-207 (1997-11-22)
Previous studies demonstrated that DBA/2J (DBA) mice performed poorly while C57BL/6J (C57) mice performed normally on a number of complex learning and memory tasks. Chronic oxiracetam treatment dramatically improved the performance of DBA mice but not that of C57 mice
C Mondadori et al.
Behavioural brain research, 77(1-2), 223-225 (1996-05-01)
The memory-enhancing effects of a single treatment with the GABAB antagonist CGP 36,742 (10 mg/kg) or the nootropic agent oxiracetam (100 mg/kg) given immediately after a learning experience ('post-trial') remain detectable for at least 4 months thereafter. This indicates that
R C Simpson et al.
Journal of chromatography, 631(1-2), 227-232 (1993-02-12)
Reversed-phase HPLC methodology utilizing pre-column derivatization and post-column reaction fluorimetric detection has been developed and applied to the determination of oxiracetam in human plasma. The method involves preliminary isolation of oxiracetam and internal standard from plasma by solid-phase extraction prior
X L Jiao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 29(8), 570-575 (1994-01-01)
A method was developed for the determination of oxiracetam concentration in serum and urine by HPLC. Acyclovir was used as an internal standard. The analytical column was a stainless-steel column (30 mm x 4.6 mm ID) filled with 10 microns
A Pittaluga et al.
European journal of pharmacology, 272(2-3), 203-209 (1995-01-16)
Oxiracetam, aniracetam and D-cycloserine, three putative cognition enhancers, were examined in a functional assay for NMDA receptors. Rat hippocampal slices or synaptosomes were labeled with [3H]noradrenaline and exposed to NMDA or glutamate in superfusion. NMDA (100 microM) elicited a remarkable

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