O0877
恶喹酸
quinolone antibiotic
同義詞:
5,8-二氢-5-乙基-8-氧代-1,3-二氧戊环并[4,5-g]喹啉-7-羧酸
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經驗公式（希爾表示法）:
C13H11NO5
CAS 編號:
分子量：:
261.23
UNSPSC Code:
51282935
NACRES:
NA.85
PubChem Substance ID:
EC Number:
238-750-8
Beilstein/REAXYS Number:
620635
MDL number:
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InChI key
KYGZCKSPAKDVKC-UHFFFAOYSA-N
InChI
1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
SMILES string
CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
Quality Level
antibiotic activity spectrum
Gram-negative bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
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1 of 4
本產品 | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum Gram-negative bacteria |
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - | mode of action DNA synthesis | interferes, enzyme | inhibits |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 200 |
| solubility 0.5 M NaOH: soluble 50 mg/mL | solubility - | solubility - | solubility - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
General description
化学结构：喹诺酮
Application
恶喹酸被用于研究大肠杆菌（Escherichia coli）和肠沙门氏菌（Salmonella enterica）中的新型传染性抗性机制qnrA、qnrB、qnrS和aac(6′)Ib-cr。将恶喹酸加入培养基中，可用于分离阴道加德纳菌（Gardnerella vaginalis）[1]。
Biochem/physiol Actions
恶喹酸是一种喹诺酮类抗生素。它是一种DNA促旋酶（拓扑异构酶II）抑制剂，可用于研究DNA缠绕和卷曲，并作为多巴胺再摄取抑制剂，用于多巴胺能神经传递过程的研究。
Other Notes
5g,25g
保存于密闭容器内，置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存儲類別/等級
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
J S Thompson
Journal of clinical microbiology, 21(5), 843-843 (1985-05-01)
Colistin-oxolinic acid medium is proposed as a selective isolation medium for Gardnerella vaginalis. The medium is effective in inhibiting staphylococci and gram-negative bacteria while allowing growth of G. vaginalis.
J Garcia de Mateos-Verchere et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(4), 255-259 (1999-02-03)
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in locomotor activity. This stimulation culminated at the 32 mg/kg dose and became smaller for higher doses (64-128 mg/kg). When opposed to increasing doses (50-100-200 microg/kg
Xiuhong Wang et al.
The Journal of antimicrobial chemotherapy, 65(3), 520-524 (2010-01-14)
Quinolone-mediated death of Escherichia coli has been proposed to occur by two pathways. One is blocked by inhibitors of protein synthesis; the other is not. It is currently unknown how these two pathways fit with the recent observation that hydroxyl
Hyeok Ran Kwon et al.
Pest management science, 66(6), 634-639 (2010-02-13)
Pine wilt disease (PWD) is very complex and has been reported to be caused by pine wood nematode, Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle, and its accompanying bacteria. However, there is no report on the control of PWD by antibacterial
Kalliopi C Skyrianou et al.
Journal of inorganic biochemistry, 105(10), 1273-1285 (2011-08-09)
The nickel(II) complexes with the quinolone antibacterial agents oxolinic acid, flumequine, enrofloxacin and sparfloxacin in the presence of the N,N'-donor heterocyclic ligand 2,2'-bipyridylamine have been synthesized and characterized. The quinolones act as bidentate ligands coordinated to Ni(II) ion through the
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