推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
分子量
antigen ~70 kDa
物種活性
human, rat
包裝
antibody small pack of 25 μL
濃度
~1.0 mg/mL
技術
western blot: 1-2 μg/mL using rat brain extract (S1 fraction) and A431 cell lysate
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NUMB(8650)
mouse ... Numb(18222)
rat ... Numb(29419)
相關類別
一般說明
Numb gene with 13 exons is mapped to human chromosome 14q24.3. The protein comprises 651 amino acids. It belongs to the clathrin-associated sorting protein family with two domains namely phosphotyrosine-binding (PTB) and proline-rich region (PRR) domain. Mammalian Numb gene gives rise to at least four alternatively spliced transcripts that produce four protein isoforms Numb1-4, ranging from 65 to 72 kDa.
Numb homolog-NUMB is an adaptor protein and is aberrantly expressed in cancers.
應用
Anti-NUMB (C-terminal) antibody produced in rabbit has been used in immunoblotting.
生化／生理作用
Numb homolog-NUMB may act as a tumor suppressor. It also takes part in determining the cell fate. NUMB is involved in the endocytosis and trafficking of receptors.
Numb is a critical Notch antagonist and a conserved adapter protein that plays a role in the self-renewal of NSCs and neural differentiation in the central nervous system (CNS). In neural progenitors of CNS, the functional loss of numb is implicated in embryonic lethality accompanied by precocious neuronal differentiation. It has been suggested that a switch in numb isoform expression is a critical step in cortical development. Numb1 or numb3 isoforms that contain an insertion in the proline-rich region (PRRL), promote the proliferation of neural crest stem cells (NCSCs). Numb2 or numb4 isoforms without PRR insertions (PRRS) show ectopic expression and promote neuronal differentiation.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
The association of cholesterol absorption gene numb polymorphism with coronary artery disease among Han Chinese and Uighur Chinese in Xinjiang, China
Abudoukelimu M, et al.
Lipids in Health and Disease, 14(1), 120-120 (2015)
Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain
Toriya M, et al.
Developmental Neuroscience, 28(1-2), 142-142 (2006)
Notch: from neural development to neurological disorders
Lathia JD, et al.
Journal of Neurochemistry, 107(6), 1471-1481 (2008)
Yinying Lu et al.
Hepatology (Baltimore, Md.), 62(4), 1122-1131 (2015-06-11)
The cell fate determinant Numb is aberrantly expressed in cancer. Numb is alternatively spliced, with one isoform containing a long proline-rich region (PRR(L) ) compared to the other with a short PRR (PRR(S) ). Recently, PRR(L) was reported to enhance
Phenotypic and genetic characterization of a patient with a de novo interstitial 14q24. 1q24. 3 deletion
Tassano E, et al.
Molecular Cytogenetics, 7(1), 49-49 (2014)
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