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Merck
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文件

N3911

Sigma-Aldrich

NBI 27914

≥98% (HPLC)

同義詞:

5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine

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About This Item

經驗公式（希爾表示法）:
C18H20Cl4N4
CAS號碼:
184241-44-9
分子量：:
434.19
MDL號碼:
MFCD05662281
分類程式碼代碼:
12352200
PubChem物質ID:
24278425
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

顏色

white

溶解度

DMSO: >20 mg/mL at 60 °C
H2O: insoluble

儲存溫度

2-8°C

SMILES 字串

CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl

InChI

1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)

InChI 密鑰

KNADXBVKFAUMCR-UHFFFAOYSA-N

基因資訊

human ... CRHR1(1394)

應用

NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:
  • to study its effects on steroidogenic gene expression in GD15 mouse testis
  • to study its effects on amyloid β production
  • to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

生化／生理作用

NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析證明 (COA)

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A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis
McDowell E N, et al.
PLoS ONE, 7(10), e47359-e47359 (2012)
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Koutmani Y, et al.
Testing, 29(4), 932-945 (2019)
The stress response neuropeptide CRF increases amyloid-beta production by regulating gamma-secretase activity
Park H J, et al.
The Embo Journal, 34(12), 1674-1686 (2015)
Takatoshi Kasai et al.
Cell reports, 30(1), 18-24 (2020-01-09)
The pituitary is a major hormone center that secretes systemic hormones responding to hypothalamus-derived-releasing hormones. Previously, we reported the independent pituitary induction and hypothalamic differentiation of human embryonic stem cells (ESCs). Here, a functional hypothalamic-pituitary unit is generated using human

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