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M9149

Sigma-Aldrich

Mepartricin

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About This Item

CAS號碼:
11121-32-7
MDL號碼:
MFCD00070325
分類程式碼代碼:
51101500
PubChem物質ID:
329818084

效力

3700 units Mepartricin per mg

顏色

yellow to yellow with tan cast powder

溶解度

DMF: 50 mg/mL, slightly hazy, red to red-brown

抗生素活性譜

fungi

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

COC(=O)C1C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)OC(C(C)CCC(O)CC(=O)c3ccc(N)cc3)C(C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(CC1O2)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O

InChI

1S/C59H86N2O19/c1-35-17-15-13-11-9-7-5-6-8-10-12-14-16-18-47(78-58-55(73)53(61)54(72)37(3)77-58)32-50-52(57(74)76-4)49(70)34-59(75,80-50)33-46(68)29-44(66)27-42(64)25-41(63)26-43(65)28-45(67)31-51(71)79-56(35)36(2)19-24-40(62)30-48(69)38-20-22-39(60)23-21-38/h5-18,20-23,35-37,40-42,44-47,49-50,52-56,58,62-64,66-68,70,72-73,75H,19,24-34,60-61H2,1-4H3/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t35?,36?,37-,40?,41?,42?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58+,59?/m1/s1

InChI 密鑰

GIDIUOCSTCGLRW-QJSPMWJNSA-N

一般說明

Chemical structure: macrolide

應用

Mepartricin is a polyene antibacterial with antifungal and antiprotozoal activity. It is an Amphotericin B(AmB) analogue and has been used to study scrapie. It is used as an antibiotic supplement in cell culture.
Mepartricin is used in studies on sterol biosynthesis and bacterial cell membranes. It may be incorporated into liposomes

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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E Pisani
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 67(4), 223-230 (1995-09-01)
The effects of partricin methyl ester, administered to 481 BPH patients at the dose of 150.000 U as a single administration at night for 90 days were studied in the course of a multicentre study. The favourable evolution of the
Shuji Shakuto et al.
Scandinavian journal of urology and nephrology, 39(5), 358-365 (2005-11-01)
To investigate the effects of mepartricin, a polyene macrolide antibiotic, on estrogen-induced hyperplastic prostate and seminal vesicle (SV) growth in castrated rats. Immature rats aged 3 weeks were castrated and left untreated for 1 week. Then, 17beta-estradiol benzoate (E(2)-BA) was
D Prezioso et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 48(2), 117-120 (1996-06-01)
The authors assessed the validity of a treatment with mepartricin in BPH at the dose of 150,000 U in a once-a-day evening administration for 6 months. The results from the controlled study were compared with those obtained in a homogeneous
Aldo Franco De Rose et al.
Urology, 63(1), 13-16 (2004-01-31)
To verify the efficacy of mepartricin versus placebo with regard to symptom improvement in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CPPS) and to verify a relation between hormonal levels and clinical improvement in these patients. Twenty-six patients with
[Can mepartricin be considered an antiandrogenic drug?].
C Lubrano et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 44(2), 113-116 (1992-04-01)
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