一般說明
β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily.
β2-microglobulin (B2M) is a non-glycosylated polypeptide. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.
免疫原
β2-microglobulin
應用
Anti-β2-Microglobulin antibody produced in rabbit has been used in immunoblottingand immunofluorescence.
生化／生理作用
β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis.
β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).
品質
The antiserum has been treated to remove lipoprotens.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Damien G Noone et al.
Kidney international, 90(1), 123-134 (2016-05-30)
Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise
The prognostic significance of Beta2 microglobulin in patients with hemophagocytic lymphohistiocytosis
Jiang T, et al.
Disease Markers, 2016 (2016)
Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system
Kiskova T, et al.
Placenta, 78, 36-43 (2019)
Aruna P Ambagala et al.
Archives of virology, 158(5), 955-965 (2012-12-13)
Cynomolgus macaques are widely used as an animal model in biomedical research. We have established an immortalized cynomolgus macaque fibroblast cell line (MSF-T) by transducing primary dermal fibroblasts isolated from a 13-year-old male cynomolgus macaque with a retrovirus vector expressing
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity
Su SC, et al.
The Journal of Biological Chemistry, 285(52), 40624-40634 (2010)
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