推薦產品
化驗
≥98% (TLC)
形狀
powder
顏色
white
mp
98-100 °C
應用
cell analysis
peptide synthesis
SMILES 字串
CC(S)C(=O)NCC(O)=O
InChI
1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
InChI 密鑰
YTGJWQPHMWSCST-UHFFFAOYSA-N
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相關類別
應用
N-(2-巯丙酰)甘氨酸或Tiopronin已用于：
- 制备聚乙烯亚胺(PEI)包覆金微粒(PEI-gold)，进行核酸生物传递
- 研究活性氧(ROS)在异氟醚预处理诱导的体内神经保护中的再灌注期作用
- 作为ROS抑制剂，研究其对溶血磷脂酰胆碱(LPC)诱导的炎症小体激活的影响
生化／生理作用
N-(2-巯丙酰)甘氨酸(NMPG)是一种与自身免疫性低血糖相关的硫醇化合物。它是一种可扩散抗氧化剂，可降低结肠损伤的严重程度。NMPG还可减轻髓过氧化物酶活性，刺激缺氧诱导因子-1(HIF-1)-血管内皮生长因子(VEGF)溃疡愈合途径。
N-(2-巯基丙酰基)-甘氨酸是一种自由基清除剂。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Soohwan Yum et al.
Biochemical and biophysical research communications, 443(3), 1008-1013 (2013-12-24)
We investigated anti-colitic effects of N-(2-mercaptopropionyl)-glycine (NMPG), a diffusible antioxidant, in TNBS-induced rat colitis model and a potential molecular mechanism underlying the pharmacologic effect of the antioxidant. NMPG alleviated colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuated
Wei Chen et al.
Journal of cardiovascular pharmacology, 73(5), 265-271 (2019-05-15)
Emulsified isoflurane (EI) has been shown to alleviate myocardial ischemia-reperfusion (IR) injury. However, previous reports have not been focused on the underlying mechanism. We used models of IR injury in Langendorff-isolated rat hearts to determine the relationship between the mechanism
Pyritinol
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, 2988-2989 (2006)
Sang Hyun Lee et al.
Brain research, 1723, 146405-146405 (2019-08-28)
In this in vivo and in vitro study, we aimed to investigate whether isoflurane preconditioning-induced neuronal protection is mediated by reactive oxygen species (ROS) signaling at the reperfusion stage. In the in vivo study, Sprague-Dawley rats were subjected to middle
Andrew S Goldsborough et al.
Journal of medicinal chemistry, 54(14), 4987-4997 (2011-06-11)
A major challenge in the treatment of cancer is multidrug resistance (MDR) that develops during chemotherapy. Here we demonstrate that tiopronin (1), a thiol-substituted N-propanoylglycine derivative, was selectively toxic to a series of cell lines expressing the drug efflux pump
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