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About This Item
經驗公式（希爾表示法）:
C11H17N5O11P2 · xNa+
CAS號碼:
分子量：:
457.23 (free acid basis)
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51
推薦產品
生物源
synthetic (organic)
化驗
≥92.5%
形狀
powder
溶解度
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
儲存溫度
−20°C
SMILES 字串
[Na+].[Na+].C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13
InChI
1S/C11H17N5O11P2.2Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(26-10)2-25-29(23,24)27-28(20,21)22;;/h3-4,6-7,10,17-18H,2H2,1H3,(H5-,12,13,14,19,20,21,22,23,24);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
InChI 密鑰
VSMXIKIFPKDZJA-IDIVVRGQSA-L
相關類別
一般說明
7-Methylguanosine 5′-diphosphate (m7GDP) is derived when the human decapping Dcp2 enzyme cleaves the cap of the deadenylated mRNAs during the 5′–3′ mRNA decay pathway.
應用
7-Methylguanosine 5′-diphosphate sodium salt has been used as a component of the elution buffer for the purification of 5’capped RNA.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
H Matsuo et al.
Nature structural biology, 4(9), 717-724 (1997-09-26)
eIF4E, the mRNA cap binding protein, is a master switch that controls eukaryotic translation. To be active, it must bind eIF4G and form the eIF4F complex, which also contains eIF4A. Translation is downregulated by association of eIF4E with 4E-BP, which
A B Sachs et al.
Nature structural biology, 7(5), 356-361 (2000-05-10)
The eukaryotic cap and poly(A) tail binding proteins, eIF4E and Pab1p, play important roles in the initiation of protein synthesis. The recent structures of the complex of eIF4E bound to the methylated guanosine (cap) found at the 5'end of messenger
7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by Decapping Scavenger (DcpS) enzymes and potently inhibits their activity
Wypijewska A, et al.
Biochemistry, 51(40) (2012)
DcpS can act in the 5??3? mRNA decay pathway in addition to the 3??5? pathway
Erwin VD, et al.
Proceedings of the National Academy of Sciences, 100(21) (2003)
Susan Parrish et al.
Journal of virology, 81(23), 12973-12978 (2007-09-21)
Vaccinia virus (VACV) encodes enzymes that cap the 5' end of viral mRNAs, which enhances their stability and translation. Nevertheless, recent studies demonstrated that the VACV D10 protein (VACV-WR_115) decaps mRNA, an enzymatic activity not previously shown to be encoded
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