M5280

Mastoparan, Vespula lewisii

≥97% (HPLC), powder

• 經驗公式（希爾表示法）: C₇₀H₁₃₁N₁₉O₁₅
• CAS號碼: 72093-21-1
• 分子量：: 1478.91
• Beilstein: 5491949
• MDL號碼: MFCD00076865
• 分類程式碼代碼: 41106300
• PubChem物質ID: 329818006
• NACRES: NA.32

屬性

• 生物源: synthetic
• 品質等級: 200
• 化驗: ≥97% (HPLC)
• 形狀: powder
• 顏色: white
• 儲存溫度: −20°C
• SMILES 字串: CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O
• InChI: 1S/C70H131N19O15/c1-17-40(11)55(75)69(103)88-53(35-54(74)90)68(102)87-52(34-39(9)10)67(101)83-46(25-19-22-28-71)62(96)78-45(16)61(95)86-50(32-37(5)6)65(99)79-42(13)58(92)77-43(14)60(94)85-51(33-38(7)8)66(100)80-44(15)59(93)81-47(26-20-23-29-72)63(97)82-48(27-21-24-30-73)64(98)89-56(41(12)18-2)70(104)84-49(57(76)91)31-36(3)4/h36-53,55-56H,17-35,71-73,75H2,1-16H3,(H2,74,90)(H2,76,91)(H,77,92)(H,78,96)(H,79,99)(H,80,100)(H,81,93)(H,82,97)(H,83,101)(H,84,104)(H,85,94)(H,86,95)(H,87,102)(H,88,103)(H,89,98)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,55-,56-/m0/s1
• InChI 密鑰: MASXKPLGZRMBJF-MVSGICTGSA-N
• 基因資訊: human ... CALM1(801) , PLA2R1(22925) ; mouse ... CALM1(12313) , PLA2R1(18779) ; rat ... CALM1(24242) , PLA2R1(295631)

描述

Amino Acid Sequence

Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2

一般說明

Mastoparan is a cationic, amphiphilic, tetradecapeptide amide. It is composed of the restricted amino acid and the repeated sequence. This protein is a nonspecific secretagogue isolated from venom of wasp.

應用

Mastoparan has been used as a calmodulin antagonist.

生化／生理作用

Mast cell degranulating peptide. Activates phospholipase A₂; inhibits calmodulin. Cell permeable; stimulates exocytosis and phosphoinositide breakdown.

Mastoparan effectively stimulates exocytosis from diverse mammalian cells. The encoded protein facilitates the secretion of histamine from mast cells, serotonin from platelets, catecholamines from chromaffin cells and prolactin from the anterior pituitary. In addition, it is also involved in activation of Phospholipase A2 and phosphoinositides (Pl) break down. Mastoparan functions as an inhibitor for calmodulin-stimulated phosphodiesterase. Mastoparan helps in mitochondrial permeability transition by enhancing an apparent bimodal mechanism of action.

其他說明

Lyophilized from 0.1% TFA in H2O

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)