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Merck
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重要文件

M5046

Sigma-Aldrich

(±)-α-Methyl-(4-sulfonophenyl)glycine

同義詞:

MSPG

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About This Item

經驗公式(希爾表示法):
C9H11NO5S
CAS號碼:
分子量::
245.25
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

儲存溫度

2-8°C

SMILES 字串

CC(N)(C(O)=O)c1ccc(cc1)S(O)(=O)=O

InChI

1S/C9H11NO5S/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H,13,14,15)

InChI 密鑰

MVDSFPIEJILRME-UHFFFAOYSA-N

生化/生理作用

Antagonist at Group III metabotropic glutamate receptors.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Ivana Pulić et al.
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Ersin Yavas et al.
ACS chemical neuroscience, 8(2), 320-328 (2017-01-26)
The N-methyl-d-aspartate (NMDA) receptor antagonist, phencyclidine, induces behavioral changes in rodents mimicking symptoms of schizophrenia, possibly mediated through dysregulation of glutamatergic control of mesolimbic dopamine release. We tested the hypothesis that NMDA receptor activation modulates accumbens dopamine release, and that
D E Jane et al.
Neuropharmacology, 34(8), 851-856 (1995-08-01)
The depression of the monosynaptic excitation of neonatal rat motoneurones produced by the metabotropic glutamate receptor (mGluR) agonists (1S,3S)-1-aminocyclopentane-1, 3-dicarboxylate (ACPD) or L-2-amino-4-phosphonobutyrate (L-AP4) was antagonized by three novel phenylglycine analogues: (RS)-alpha-methyl-4-sulphonophenylglycine (MSPG), (RS)-alpha-methyl-4-phosphonophenylglycine (MPPG) and (RS)-alpha-methyl-4-tetrazolylphenylglycine (MTPG). The potencies
Lorenzo Caputi et al.
Nature chemical biology, 16(4), 383-386 (2020-02-19)
Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate
J S Bedingfield et al.
European journal of pharmacology, 309(1), 71-78 (1996-08-01)
The metabotropic glutamate (mGlu) receptor antagonist properties of novel phenylglycine analogues were investigated in adult rat cortical slices (mGlu receptors negatively coupled to adenylyl cyclase), neonatal rat cortical slices and in cultured rat cerebellar granule cells (mGlu receptors coupled to

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