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Merck
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文件

M4603

Sigma-Aldrich

乙酰基-[Nle4，Asp5，D-2-Nal7，Lys10]-环-α-黑素细胞刺激素酰胺片段4-10

≥95% (HPLC)

同義詞:

SHU9119

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About This Item

經驗公式（希爾表示法）:
C54H71N15O9
分子量：:
1074.24
MDL號碼:
MFCD02093607
分類程式碼代碼:
51111800
NACRES:
NA.32

品質等級

200

化驗

≥95% (HPLC)

UniProt登錄號

P01189

儲存溫度

−20°C

基因資訊

human ... POMC(5443)

Amino Acid Sequence

Ac-Nle-cyclo(Asp-His-Nal-Arg-Trp-Lys-NH2)

生化／生理作用

筛选环状内酰胺黑皮质素激动剂MTII的类似物导致了拟南芥SHU9119的鉴定。该化合物与刺鼠肽具有相同的药理特性，因为它是黑皮质素-4受体的有效拮抗剂和黑皮质素-3受体的较弱拮抗剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Anna Fosch et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely
V J Hruby et al.
Journal of medicinal chemistry, 38(18), 3454-3461 (1995-09-01)
The cloning of the melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) receptors (MC1-R and MC2-R, respectively) recently has led to the identification of three additional melanocortin receptors, MC3-R, MC4-R, and MC5-R. The MC2 receptor primarily recognizes only ACTH peptides, but
W Fan et al.
Nature, 385(6612), 165-168 (1997-01-09)
Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone

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