M186

R(+)-甲酰胺

5 mg/mL in absolute ethanol, ≥96% (HPLC)

• 同義詞: AM-356, R(+)-Arachidonyl-1′-hydroxy-2′-propylamide
• 經驗公式（希爾表示法）: C₂₃H₃₉NO₂
• CAS號碼: 157182-49-5
• 分子量：: 361.56
• EC號碼: 200-578-6
• MDL號碼: MFCD00467914
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24896698

屬性

• 品質等級: 100
• 化驗: ≥96% (HPLC)
• 光學活性: [α]/D +8.7°, c = 4 in chloroform(lit.)
• 藥物控制: regulated under CDSA - not available from Sigma-Aldrich Canada
• 儲存條件: desiccated; protect from light; under inert gas
• 濃度: 5 mg/mL in absolute ethanol
• 儲存溫度: −20°C
• SMILES 字串: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@H](C)CO
• InChI: 1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(26)24-22(2)21-25/h7-8,10-11,13-14,16-17,22,25H,3-6,9,12,15,18-21H2,1-2H3,(H,24,26)/b8-7-,11-10-,14-13-,17-16-/t22-/m1/s1
• InChI 密鑰: SQKRUBZPTNJQEM-FQPARAGTSA-N
• 基因資訊: mouse ... Cnr1(12801) , Cnr2(12802) ; rat ... Cnr1(25248)

描述

生化／生理作用

R(+)-Methanandamide is metabolically stable congener of anandamide that has higher affinity for the cannabinoid receptor. Of the analogs tested, (R)-methanandamide exhibited the highest affinity for the cannabinoid receptor with a Ki of 20 +/- 1.6 nM, 4-fold lower than that of anandamide (Ki = 78 +/- 2 nM). (R)-methanandamide exhibits high stability to aminopeptidase hydrolysis. Experiments with mice have demonstrated that (R)-methanandamide also posseses cannabimimetric properties in vivo, as established by the four tests of hypothermia, hypokinesia, ring immobility, and antinociception.

特點和優勢

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS02,GHS07
• 訊號詞: Danger
• 危險聲明: H225,H319
• 防範說明: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Flam. Liq. 2
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 57.2 °F
• 閃點（°C）: 14 °C
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter