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Merck
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重要文件

M1684

Sigma-Aldrich

(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine

同義詞:

(2S,3S,4S)-MCCG

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About This Item

經驗公式(希爾表示法):
C7H11NO4
CAS號碼:
分子量::
173.17
MDL號碼:
分類程式碼代碼:
12352200

溶解度

H2O: >10 mg/mL

儲存溫度

−20°C

SMILES 字串

C[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O

生化/生理作用

Potent antagonist at mGluR2 metabotropic glutamate receptors

分析報告

Stereochemistry confirmed by x-ray crystallography

分析證明 (COA)

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P J Attwell et al.
Brain research, 805(1-2), 138-143 (1998-09-12)
The anticonvulsant effects of intracerebral administration of the highly potent group II metabotropic glutamate receptor agonist, DCG-IV, were tested in fully kindled rats following daily electrical stimulation of the basolateral amygdala. The agonist caused a dose-dependent increase in the generalized
T Knöpfel et al.
Neuropharmacology, 34(8), 1099-1102 (1995-08-01)
The two reported metabotropic glutamate receptor (mGluR) antagonists, alpha-methyl-cyclopropyl glycine (MCCG) and alpha-methyl-aminophosphonobutyrate (MAP4) were tested on the mGluR1b, mGluR2 and mGluR4a subtypes of human mGluRs. Neither MCCG (500 microM) nor MAP4 (500 microM) antagonized the activation of mGluR1b by

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