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Merck
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文件

M109

Sigma-Aldrich

2-Methylserotonin maleate salt

≥98% (HPLC)

同義詞:

2-Methyl-5-hydroxytryptamine maleate salt, 3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol maleate salt

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About This Item

經驗公式（希爾表示法）:
C11H14N2O · C4H4O4
CAS號碼:
78263-91-9
分子量：:
306.31
MDL號碼:
MFCD00082467
分類程式碼代碼:
12352200
PubChem物質ID:
24278101

化驗

≥98% (HPLC)

形狀

solid

顏色

tan

溶解度

H2O: 4.5 mg/mL

儲存溫度

−20°C

SMILES 字串

OC(=O)\C=C/C(O)=O.Cc1[nH]c2ccc(O)cc2c1CCN

基因資訊

human ... HTR3A(3359) , HTR3B(9177)

生化／生理作用

5-HT3 serotonin receptor agonist.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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D M Gillies et al.
European journal of pharmacology, 303(1-2), 1-12 (1996-05-06)
5-Hydroxytryptamine (5-HT) is involved in the modulation of dopaminergic activity in the mesolimbic system, but its sites of action and the receptors involved are not well understood. Locomotor activity responses in rats were monitored in Animex automated activity boxes following
T Endo et al.
Research communications in molecular pathology and pharmacology, 104(2), 145-155 (2000-01-14)
The object of this study was to evaluate the involvement of 5-HT3 receptors in the regulation of 5-HT release from the small intestine using ferrets, an animal model of emesis. 2-Methyl-5-HT, a 5-HT3 receptor agonist, produced a concentration-dependent increase of
A M Ismaiel et al.
Journal of medicinal chemistry, 33(2), 755-758 (1990-02-01)
alpha-Methyl-5-hydroxytryptamine (alpha-Me-5-HT; 2) and 2-methyl-5-hydroxytryptamine (2-Me-5-HT; 3) are considered to be 5-HT2-selective and 5-HT3-selective agents, respectively. These agents were synthesized and examined at serotonin (5-HT) binding sites because there is relatively little documentation as to their selectivity and because they
Weixia Zhong et al.
PloS one, 9(8), e104718-e104718 (2014-08-15)
Stimulation of 5-HT3 receptors (5-HT3Rs) by 2-methylserotonin (2-Me-5-HT), a selective 5-HT3 receptor agonist, can induce vomiting. However, downstream signaling pathways for the induced emesis remain unknown. The 5-HT3R channel has high permeability to extracellular calcium (Ca(2+)) and upon stimulation allows

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