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Key Documents

L6795

Sigma-Aldrich

LY311727

≥98% (HPLC), powder

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About This Item

經驗公式(希爾表示法):
C22H27N2O5P
CAS號碼:
分子量::
430.43
MDL號碼:
分類程式碼代碼:
41106300
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: ≥15 mg/mL

起源

Eli Lilly

儲存溫度

2-8°C

SMILES 字串

CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc3ccccc3

InChI

1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)

InChI 密鑰

OPWQYOUZRHDKBR-UHFFFAOYSA-N

生化/生理作用

LY311727 is an orally active; potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor.

特點和優勢

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Shulin Hou et al.
Scientific reports, 7(1), 10815-10815 (2017-09-09)
Secreted phospholipases A
Deepti Dabral et al.
Cells, 8(4) (2019-04-17)
The fundamental molecular mechanism underlying the membrane merger steps of regulated exocytosis is highly conserved across cell types. Although involvement of Phospholipase A₂ (PLA₂) in regulated exocytosis has long been suggested, its function or that of its metabolites-a lyso-phospholipid and

文章

磷脂酶A2(PLA2)代表的是一类可水解甘油磷脂的sn-2酯以产生脂肪酸和溶血磷脂的酶。目前已知的是,其中一些酶可在哺乳动物细胞中释放花生四烯酸以用于类花生酸的生物合成,因此PLA2抑制剂的开发引起了相当大的兴趣。基于氨基酸序列,现有超过12种不同的哺乳动物PLA2以及多种非哺乳动物的形式,它们被归类为具有多个亚组的14个组别。

Phospholipase A2 (PLA2) enzymes hydrolyze glycerophospholipids, yielding arachidonic acid; inhibition targets eicosanoid biosynthesis.

Discover Bioactive Small Molecules for Lipid Signaling Research

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