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Merck
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重要文件

L5140

Sigma-Aldrich

(−)-Leukotriene A4 methyl ester

~98%, triethylamine:hexane solution

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About This Item

經驗公式(希爾表示法):
C21H32O3
CAS號碼:
分子量::
332.48
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:

化驗

~98%

形狀

triethylamine:hexane solution

官能基

ester

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CCCCC\C=C/C/C=C\C=C\C=C\[C@@H]1O[C@H]1CCCC(=O)OC

InChI

1S/C21H32O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-16-19-20(24-19)17-15-18-21(22)23-2/h7-8,10-14,16,19-20H,3-6,9,15,17-18H2,1-2H3/b8-7-,11-10-,13-12+,16-14+/t19-,20-/m0/s1

InChI 密鑰

WTKAVFHPLJFCMZ-NIBLXIPLSA-N

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生化/生理作用

Precursor of leukotriene C4.

包裝

在氩气下包装

注意

Free acid is unstable; hydrolysis is not recommended.

外觀

Solution in triethylamine: hexane (2:98)

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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C Prakash et al.
Prostaglandins, 37(2), 251-258 (1989-02-01)
C-20 Trideuterated leukotriene A4 methyl ester was prepared by Wittig condensation of a deuterated C9-phosphonium salt with a C11-epoxydienal. It was then treated separately with glutathione, cysteinylglycine and cysteine. The resulting esters were saponified to give C-20 trideuterated leukotrienes C4
Shimizu, T., et al.
Proceedings of the National Academy of Sciences of the USA, 81, 689-689 (1987)
G Maury et al.
Biochemistry international, 15(6), 1127-1135 (1987-12-01)
It has been shown that various glutathione transferases can synthesize leukotriene C4, or its methyl ester, from glutathione and leukotriene A4. We questioned whether the same enzymes could be used to resolve racemic leukotriene A4 methyl ester (more easily prepared
B Mannervik et al.
FEBS letters, 175(2), 289-293 (1984-10-01)
Six major basic cytosolic glutathione transferases from rat liver catalyzed the conversion of leukotriene A4 methyl ester to the corresponding leukotriene C4 monomethyl ester. Glutathione transferase 4-4, the most active among these enzymes, had a Vmax of 615 nmol X
Iu Iu Belosludtsev et al.
Bioorganicheskaia khimiia, 13(8), 1125-1131 (1987-08-01)
The strategy of acyclic eicosanoid synthesis via polyacetylenic intermediates is examplified by the synthesis of the racemic leukotriene A4 methyl ester. Leukotriene synthons, namely, trideca-1,4,7-triyne and methyl 6-formyl-5,6-trans-epoxyhexanoate, were synthesised using propargylic alcohol (thrice) and 1-heptyne as starting materials. In

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