K3644

K 858

≥98% (HPLC)

• 同義詞: K858, N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadia zol-2-yl)acetamide
• 經驗公式（希爾表示法）: C₁₃H₁₅N₃O₂S
• CAS號碼: 72926-24-0
• 分子量：: 277.34
• MDL號碼: MFCD00181155
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329817139
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• 溶解度: DMSO: ≥20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
• InChI: 1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
• InChI 密鑰: JEFVYQYZCAVNTP-UHFFFAOYSA-N

描述

生化／生理作用

Eg5 is a key protein involved in the formation of bipolar spindles. K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor. The compound induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable