推薦產品
一般說明
白介素-6是一种参与造血、炎症和免疫反应的多效性细胞因子。IL-6由巨噬细胞，树突状细胞和B细胞分泌，以响应TNF-α，PGDF和IL-1。IL-6的信号传导是由异二聚体受体IL-6R介导的，该受体由IL-6Rα（可溶性因子）和gp130（有时称为IL-6Rβ）组成。gp130是下游信号转导的关键组成部分。响应IL-6，gp130激活JAK家族，STATs，MAPK和Ras蛋白的激酶。 IL-6介导的信号传导对于T细胞和B细胞的正常发育至关重要，并且与许多疾病有关，例如类风湿关节炎，克罗恩病，脓毒症，发热，系统性红斑狼疮，骨质疏松症和胰岛素耐受。单克隆抗白介素-6抗体识别人IL-6。该抗体与重组小鼠IL-6或重组人IL-6 sR、OSM、LIF CNTF或IL-11或重组马gp130无交叉反应性。
特異性
该抗体能够中和重组人IL-6的生物活性。该抗体与重组小鼠IL-6或重组人IL-6 sR、OSM、LIF CNTF或IL-11或重组马gp130无交叉反应性。
免疫原
重组人 IL-6。
應用
单克隆抗白介素-6抗体可用于ELISA，最小值抗体浓度为4μg/ml。对于免疫印迹，可使用1-2 μg/mL的工作抗体浓度。该抗体可用于中和测定；ND50为0.01-0.15 μg/ml。为了中和来自人外周血单核细胞的IL-6，使用了2.5μ g/ml的浓度。
外觀
从磷酸盐缓冲盐水中的0.2 μm过滤溶液冻干。
準備報告
使用蛋白A纯化。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Not finding the right product?
Try our 產品選擇工具.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Mysoon M Al-Ansari et al.
Oncotarget, 9(78), 34681-34690 (2018-11-10)
The ATR protein kinase is a master regulator of the cellular responses to DNA damage and replication stresses. Despite these crucial physiological roles, the implication of ATR in human carcinogenesis remains elusive. We have shown here that the ATR level
Cristiane H Squarize et al.
Neoplasia (New York, N.Y.), 8(9), 733-746 (2006-09-21)
The development of head and neck squamous cell carcinoma (HNSCC) involves the accumulation of genetic and epigenetic alterations in tumor-suppressor proteins, together with the persistent activation of growth-promoting signaling pathways. The activation of epidermal growth factor receptor (EGFR) is a
Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7.
ZuFu Lu et al.
Stem cells translational medicine, 9(3), 403-415 (2020-01-07)
The induced pluripotent stem cell (iPSC) is a promising cell source for tissue regeneration. However, the therapeutic value of iPSC technology is limited due to the complexity of induction protocols and potential risks of teratoma formation. A trans-differentiation approach employing
The novel differentiation of human blood mononuclear cells into CD1a-negative dendritic cells is stimulated in the absence of exogenous cytokines by an extract prepared from pinecones
Bradley WG et al
Immunopharmacology, 3, 209-223 (2003)
T Gustot et al.
Gut, 54(4), 488-495 (2005-03-09)
Soluble cytokine receptors (sCRs) modulate the in vivo activity of cytokines. Deficient sCR production could participate in the pathogenesis and course of Crohn's disease (CD). The aim of the study was to examine the profile of sCRs in CD patients
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務