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Merck
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重要文件

I7026

Sigma-Aldrich

Anti-Insulin-like Growth Factor Binding Protein-4 antibody produced in goat

affinity isolated antibody, lyophilized powder

同義詞:

Anti-IGFBP-4

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About This Item

MDL號碼:
分類程式碼代碼:
51111800

生物源

goat

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

lyophilized powder

物種活性

human

技術

indirect ELISA: 0.5-1.0 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL

UniProt登錄號

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... IGFBP4(3487)

一般說明

Insulin-like growth factor binding protein-4 (IGFBP-4) is a 26kD (approx.) protein expressed highly in non-paranchymal cells of the liver. IGFBP-4 is also expressed in spleen, liver, lung, kidney, adrenal, testis, heart, brain cortex, stomach and hypothalamus. It has a pivotal role in protecting cells from overstimulation caused by IGFs or towards activating the alternate transmembrane signaling pathways that are inhibited by IGF exposure. Anti-Insulin-like Growth Factor Binding Protein 4(IGFBP-4) antibody can be used in western blotting. Goat anti-IGFBP-4 antibody reacts specifically with recombinant human IGFBP-4. The product has shown no cross-reactivity for recombinant human IGFBP-1, recombinant human IGFBP-2, recombinant human IGFBP-3, recombinant human IGFBP-5 and recombinant human IGFBP-6.

特異性

By immunoblotting and ELISA, the antibody show no cross-reactivity with recombinant human IGFBP-2, recombinant human IGFBP-3, recombinant human IGFBP-1, recombinant human IGFBP-5, and recombinant human IGFBP-6.

免疫原

purified, NSO-derived, recombinant human insulin-like growth factor binding protein 4.

應用

Anti-Insulin-like Growth Factor Binding Protein-4(IGFBP-4) antibody can be used in neutralization and indirect ELISA.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

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S Shimasaki et al.
Molecular endocrinology (Baltimore, Md.), 4(10), 1451-1458 (1990-10-01)
cDNA clones encoding a novel insulin-like growth factor-binding protein (IGFBP) purified from rat serum and human bone cell-conditioned medium have been isolated from rat liver and human placenta, liver, and ovary cDNA libraries. The deduced amino acid sequences of the
Insulin-like growth factors and their binding proteins: biological actions.
J I Jones et al.
Endocrine reviews, 16(1), 3-34 (1995-02-01)

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