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Merck
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I1646

Sigma-Aldrich

白细胞介素-3 人

IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

同義詞:

hIL-3, IL-3

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.77

生物源

human

品質等級

重組細胞

expressed in E. coli

化驗

≥97% (HPLC and SDS-PAGE)

形狀

lyophilized powder

效力

≤1.0 ng/mL ED50/EC50

品質

endotoxin tested

分子量

15 kDa

包裝

pkg of 10 and 50 μg

儲存條件

avoid repeated freeze/thaw cycles

技術

cell culture | mammalian: suitable

雜質

≤0.1 EU/μg

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... IL3(3562)

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生化/生理作用

白介素3(IL-3)是一种多功能蛋白,起初被称为克隆形成单位刺激活性(CFU-SA),由活化的T淋巴细胞产生。IL-3在多能造血祖细胞的早期发育中可支持多谱系克隆的形成。IL-3已显示出可从琼脂悬浮的骨髓细胞诱导巨噬细胞、嗜中性粒细胞、肥大细胞和巨核细胞的克隆形成。IL-3也可与IL-2发生互作,以刺激T淋巴细胞的生长并诱导活化B细胞分泌IgG。IL-3的其他同义词包括泛特异性造血素、多克隆刺激因子、肥大细胞生长因子、爆发促进活性、组胺生成细胞刺激因子、P细胞刺激因子和WEHI-3因子。

外觀

无添加剂冻干。已经过0.2 μm滤器过滤。

分析報告

通过剂量依赖性刺激人TF-1细胞的增殖来测量生物活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Bingrui Wang et al.
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Ribosomal protein dysfunction causes diverse human diseases, including Diamond-Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-specific defects, are still poorly understood. In the present study, we
Ding Wang et al.
iScience, 26(6), 106917-106917 (2023-06-28)
The role of SET domain containing 7 (SETD7) during human hematopoietic development remains elusive. Here, we found that deletion of SETD7 attenuated the generation of hematopoietic progenitor cells (HPCs) during the induction of hematopoietic differentiation from human embryonic stem cells
S Yousefi et al.
Allergy, 70(9), 1184-1188 (2015-06-05)
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report
Orit Uziel et al.
Biochemical and biophysical research communications, 450(1), 274-282 (2014-06-08)
Treatment with erythropoietin (EPO) in several cancers is associated with decreased survival due to cancer progression. Due to the major importance of telomerase in cancer biology we hypothesized that some of these effects may be mediated through EPO effect on
Hai Zhou et al.
Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production

文章

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

條款

生成人類誘導多能幹細胞 (iPSC) 的幹細胞重編方案,包括以病毒和非病毒 RNA 為基礎的方法。

Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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