推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
免疫原序列
DSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSP
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... IP6K1(9807)
一般說明
Inositol hexakisphosphate kinase (IP6K1) is encoded by the gene mapped to human chromosome 3p21.31. The encoded protein belongs to the family of inositol hexakisphosphate (IP6) proteins and is widely expressed.
免疫原
inositol hexakisphosphate kinase 1 recombinant protein epitope signature tag (PrEST)
應用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
- Western Blotting (1 paper).
- immunofluorescence.
- fluorescence-activated cell sorting (FACS).
生化／生理作用
Inositol hexakisphosphate kinase 1 (IP6K1) is involved in the synthesis of diphosphoinositol pentakisphosphate. It interacts with cullin–RING ubiquitin ligase-4 (CRL4) and has a role in DNA homologous recombination repair. In addition, IP6K1 is also implicated in chromatin modifications and spermatogenesis. Elevated expression or mutation of IP6K1 is associated with the pathogenesis of type 2 diabetes mellitus and crohn′s disease. IP6K1 plays a vital role in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement and Golgi maintenance. IP6K1 controls DNA repair and cell death by mediating disassembly of the cullin-RING ubiquitin ligase 4 (CRL4)-COP9 signalosome (CSN) complex.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST79496
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Crocco P
Biochimica et Biophysica Acta, 1862(9), 1766-1773 (2016)
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
Padmanabhan U
The Journal of Biological Chemistry, 284(16), 10571-10582 (2009)
Feng Rao et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(45), 16005-16010 (2014-10-29)
Inositol polyphosphates containing an energetic pyrophosphate bond are formed primarily by a family of three inositol hexakisphosphate (IP6) kinases (IP6K1-3). The Cullin-RING ubiquitin ligases (CRLs) regulate diverse biological processes through substrate ubiquitylation. CRL4, comprising the scaffold Cullin 4A/B, the E2-interacting
Josefine Sandström et al.
Molecular and clinical oncology, 14(5), 94-94 (2021-03-27)
The inositol hexakisphosphate kinase (IP6K) 1 and 2 genes are localized at 3p21.31, a highly altered gene-dense chromosomal region in cancer. The IP6Ks convert IP6 to IP7, which inhibits activation of the tumor-promoting PI3K/Akt/mTOR signaling pathway. IP6K2 has been suggested
Gangling Liao et al.
ACS pharmacology & translational science, 4(2), 780-789 (2021-04-17)
Inositol hexakisphosphate kinases (IP6Ks) catalyze pyrophosphorylation of inositol hexakisphosphate (IP6) into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (IP7), which is involved in numerous areas of cell physiology including glucose homeostasis, blood coagulation, and neurological development. Inhibition of IP6Ks may be effective for the treatment
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