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Key Documents

H3288

Sigma-Aldrich

HEMADO

≥99% (HPLC), solid

同義詞:

2-(1-Hexynyl)-N6-methyladenosine

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About This Item

經驗公式(希爾表示法):
C17H23N5O4
CAS號碼:
分子量::
361.40
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

化驗

≥99% (HPLC)

形狀

solid

顏色

white

溶解度

DMSO: 16 mg/mL

儲存溫度

2-8°C

SMILES 字串

CCCCC#Cc1nc(NC)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1

InChI

1S/C17H23N5O4/c1-3-4-5-6-7-11-20-15(18-2)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,3-5,8H2,1-2H3,(H,18,20,21)/t10-,13-,14-,17-/m1/s1

InChI 密鑰

KOCIMZNSNPOGOP-IWCJZZDYSA-N

生化/生理作用

A3 adenosine receptor agonist

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

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Rosaria Volpini et al.
Journal of medicinal chemistry, 45(15), 3271-3279 (2002-07-12)
A series of N(6)-alkyl-2-alkynyl derivatives of adenosine (Ado) have been synthesized and evaluated for their affinity at human A(1), A(2A), and A(3) receptors and for their potency at A(2B) adenosine receptor subtypes. The corresponding 2-(1-alkynyl) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) and
Kerry Barkan et al.
Scientific reports, 10(1), 20781-20781 (2020-11-29)
The adenosine A3 receptor (A3R) belongs to a family of four adenosine receptor (AR) subtypes which all play distinct roles throughout the body. A3R antagonists have been described as potential treatments for numerous diseases including asthma. Given the similarity between
Leigh A Stoddart et al.
British journal of pharmacology, 171(16), 3827-3844 (2014-04-23)
The highly conserved tryptophan (W6.48) in transmembrane domain 6 of GPCRs has been shown to play a central role in forming an active conformation in response to agonist binding. We set out to characterize the effect of this mutation on

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