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Merck
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重要文件

H3021

Sigma-Aldrich

Antiflammin-2

≥97% (HPLC)

同義詞:

Anti-inflammatory peptide 2, His-Asp-Met-Asn-Lys-Val-Leu-Asp-Leu

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About This Item

經驗公式(希爾表示法):
C46H77N13O15S
CAS號碼:
分子量::
1084.25
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

化驗

≥97% (HPLC)

成份

Peptide content, ~65%

儲存溫度

−20°C

SMILES 字串

CSCCC(NC(=O)C(CC(O)=O)NC(=O)C(N)Cc1cnc[nH]1)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(O)=O

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Wayne B Anderson et al.
Chemical research in toxicology, 17(5), 650-662 (2004-05-18)
Dichloroacetic acid (DCA) is a drinking water contaminant, a therapeutic agent, and a rodent carcinogen. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of a range of alpha-haloalkanoates and the cis-trans isomerization of maleylacetoacetate. GSTZ1-1 catalyzes the bioactivation of fluorine-lacking dihaloacetates
Q Li et al.
Ocular immunology and inflammation, 6(2), 65-73 (1998-08-05)
Phospholipase A2s (PLA2s) are a family of esterases that initiate the arachidonic acid cascade, which results in the production of numerous inflammatory mediators. We investigated the expression of Group I and II PLA2 proteins and Group II mRNA in normal
Degradation of antiflammin 2 in aqueous solution.
J L Wolfe et al.
Journal of pharmaceutical sciences, 83(12), 1762-1764 (1994-12-01)
J M Ye et al.
Journal of pharmaceutical sciences, 85(7), 695-699 (1996-07-01)
Antiflammin 2 (HDMNKVLDL, AF2) is a synthetic peptide derived from the region of highest sequence similarity of lipocortin I and uteroglobin, and is a potent antiinflammatory agent without any known side effects of corticosteroids. The antiinflammatory activity of AF2 has
S Lloret et al.
Biochemical pharmacology, 50(3), 347-353 (1995-07-31)
Antiflammins are synthetic peptides with sequence homology to proteins inhibitory for phospholipase A2 (EC 3.1.1.4). The effect of antiflammin 2 on murine arachidonate or 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear oedema has been studied. Topical application of arachidonic acid (AA) produced a

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