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H2529

Sigma-Aldrich

α-Hydroxytriazolam

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About This Item

經驗公式(希爾表示法):
C17H12Cl2N4O
CAS號碼:
分子量::
359.21
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

品質等級

SMILES 字串

OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12

InChI

1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2

InChI 密鑰

BHUYWUDMVCLHND-UHFFFAOYSA-N

生化/生理作用

Triazolam metabolite

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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Jin, L., et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 654, 77-77 (1994)
P Coassolo et al.
Journal of chromatography, 274, 161-170 (1983-05-13)
A gas--liquid chromatographic method for the simultaneous determination of triazolam and its major hydroxy metabolite (1-hydroxymethyltriazolam) in human plasma and urine is described. After addition of two internal standards to the biological fluid, extraction at pH 9, acid washing, back-extraction
Barry Levine et al.
Journal of analytical toxicology, 26(1), 52-54 (2002-03-13)
The case of a 77-year-old woman who was found dead in her bathtub with her head clearly above the water line is presented. The decedent had a medical history of depression, liver disease, spinal stenosis, and diabetes mellitus. An empty
W J Adams et al.
Journal of pharmaceutical sciences, 72(10), 1185-1189 (1983-10-01)
The absorption of triazolam from pelleted drug-diet mixtures by mice under steady-state conditions was determined for doses up to 150 mg/kg/day by measuring alpha-hydroxytriazolam, the principal urinary metabolite of triazolam in the mouse, in urine samples collected over a 24-hour
O Dehlin et al.
European journal of clinical pharmacology, 25(1), 91-94 (1983-01-01)
Serum triazolam levels were determined in eight geriatric patients (average age 80 years) on Days 1 and 7 of administration of triazolam 0.25 mg once daily, 1 h after a standard breakfast. Triazolam was rapidly absorbed reaching average peak concentrations

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