生物源
chicken
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human, rat
製造商／商標名
Genway 15-288-22823
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... BAT3(7917)
一般說明
BAT3 is a gene from major histocompatibility complex. In humans, it is localized in the class III region of the human major histocompatibility complex on chromosome 6. It consists of an ubiquitin homology region at the N-terminal end, short tracts of polyproline and polyglycine, a zinc finger-like domain and a nuclear localization signal (NLS) at the C- terminus end. It is a member of BAG family of proteins. The major responsibility of BAG proteins is to negatively control the chaperone function of the Hsp70 family.
免疫原
Immunogen Sequence: GI # 18375632, sequence 2-250
Recombinant HLA-B associated transcript-3 isoform b
應用
Anti-BAT3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化／生理作用
Large proline-rich protein BAT3 is a protein encoded by the BAT3 gene in humans. It is very rich in proline and includes short tracts of polyproline, polyglycine and charged amino acids. BAT3 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin and synapsin. It has distinct functions in the cytosol and in the nucleus. It is also associated with controlling of apoptosis and regulating heat shock protein (HSP) 70 activity.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
S T Manchen et al.
Biochemical and biophysical research communications, 287(5), 1075-1082 (2001-10-06)
Human Scythe (also known as BAT3) has been implicated in the control of apoptosis and regulating heat shock protein (HSP) 70 activity. We have attempted to further characterize the role of human Scythe in HeLa cells by studying the cellular
Manu Rangachari et al.
Nature medicine, 18(9), 1394-1400 (2012-08-07)
T cell immunoglobulin and mucin domain–containing 3 (Tim-3) is an inhibitory receptor that is expressed on exhausted T cells during infection with HIV-1 and hepatitis C virus. By contrast, Tim-3 expression and function are defective in multiple human autoimmune diseases.
Toru Sasaki et al.
Genes & development, 21(7), 848-861 (2007-04-04)
In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still unclear. Here, we describe an essential role for HLA-B-associated transcript 3
Nadine Kämper et al.
PloS one, 7(4), e35972-e35972 (2012-05-05)
The human lymphocyte antigen (HLA) encoded BAT3/BAG6 recently attracted interest as a regulator of protein targeting and degradation, a function that could be exerted in the cytosol and in the nucleus. The BAT3 gene was described to consist of 25
J Banerji et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(6), 2374-2378 (1990-03-01)
A large number of genes has been identified previously between the class I and class II gene families within the class III region of the human major histocompatibility complex. The complete sequences of two of these genes, BAT2 and BAT3
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