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GW21184P

Sigma-Aldrich

Anti-c-Myc (ab1) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-Myc proto-oncogene protein

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

chicken

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

rat, mouse, human

製造商/商標名

Genway 15-288-21184P

技術

indirect ELISA: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... MYC(4609)

免疫原

Immunogen Sequence: GI # 12962935, sequence 410-419
Synthetic peptide of V-myc myelocytomatosis viral oncogene homolog.

應用

Anti-c-Myc (ab1) antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Myc (c-Myc) is a regulatory gene and encodes for a transcription factor. It is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. Myc is associated with aggressive behaviour in several cancers. c-MYC gain with lung adenocarcinoma is a candidate for additional first-line treatment to mitigate increased risk for disease progression and death. It plays an important role in the pathogenesis of B-cell prolymphocytic leukemia (B-PLL).

外觀

Solution in phosphate buffered saline containing 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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Ellen Flatley et al.
American journal of clinical pathology, 142(3), 347-354 (2014-08-16)
B-cell prolymphocytic leukemia (B-PLL) remains a controversial entity, and its molecular pathogenesis is largely unknown. Patients are older, typically having marked lymphocytosis and splenomegaly in the absence of lymphadenopathy. It is defined as a mature B-cell leukemia with more than
A N Seo et al.
British journal of cancer, 110(11), 2688-2699 (2014-05-09)
c-MYC copy number gain (c-MYC gain) has been associated with aggressive behaviour in several cancers. However, the role of c-MYC gain has not yet been determined in lung adenocarcinomas classified by genetic alterations in epidermal growth factor receptor (EGFR), KRAS
Enrico Alessio et al.
Nucleic acids research, 47(4), 1653-1670 (2019-01-17)
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their subcellular

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