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GW21181

Sigma-Aldrich

Anti-VEGFR-2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-Vascular endothelial growth factor receptor 2

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

chicken

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

rat, mouse, human

製造商/商標名

Genway 15-288-21181

技術

immunohistochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... KDR(3791)

免疫原

Immunogen Sequence: GI # 9087218, sequence 51-119
Recombinant vascular endothelial growth factor receptor 2

應用

Anti-VEGFR-2 antibody produced in chicken is suitable for immunohistochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase, VEGFR-2) is a VEGF receptor and is encoded by KDR gene in humans. It plays a crutial role in controlling endothelial trafficking activity and is involved in phosphotyrosine phosphatase 1b (PTP1b). PTP1b acts as a key regulator of endothelial VEGFR2 signaling and plays a critical role in regulation of the extent of vascular tree formation. VEGFR2 may be associated with gout and hyperuricaemia risks in Malays.

外觀

Solution in phosphate buffered saline containing 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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Soumaya Hachana et al.
British journal of pharmacology, 177(9), 1949-1966 (2019-12-29)
Age-related macular degeneration (AMD) is a complex neurodegenerative disease treated by anti-VEGF intravitreal injections. As inflammation is potentially involved in retinal degeneration, the pro-inflammatory kallikrein-kinin system is a possible alternative pharmacological target. Here, we investigated the effects of anti-VEGF and
Yap W K Roseline et al.
Malaysian journal of nutrition, 18(3), 307-317 (2012-12-01)
Gout and hyperuricaemia attributed to genetic and lifestyle factors have been associated with several chronic diseases. This study aimed to determine the association and interaction effects between vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870377 and rs2071559) and dietary
PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.
Lanahan AA, Lech D, Dubrac A, et al.
Circulation, 130(11), 902-909 (2014)
Soumaya Hachana et al.
British journal of pharmacology, 175(6), 968-983 (2017-12-30)
The kinin B1 receptor contributes to vascular inflammation and blood-retinal barrier breakdown in diabetic retinopathy (DR). We investigated the changes in expression, cellular localization and vascular inflammatory effect of B1 receptors in retina of streptozotocin diabetic rats. The distribution of
Giuseppe Di Stolfo et al.
Clinical hemorheology and microcirculation, 72(1), 23-38 (2018-10-16)
Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells

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