跳轉至內容
Merck
全部照片(2)

Key Documents

G5419

Sigma-Aldrich

单克隆抗-谷氨酸脱羧酶 67(GAD67) 小鼠抗

clone K-87, purified antibody

同義詞:

抗-GAD 67

登入查看組織和合約定價


About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

K-87, monoclonal

分子量

antigen 67 kDa

物種活性

rat, mouse, human

濃度

~1 mg/mL

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:20,000 (with antigen-retrieval step)
western blot: 1:500-1:20,000 using mouse brain extract

同型

IgG1κ

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

目標翻譯後修改

unmodified

基因資訊

human ... GAD1(2571)
mouse ... Gad1(14415)
rat ... Gad1(24379)

一般說明

谷氨酸脱羧酶67(GAD67)由基因谷氨酸脱羧酶1(GAD1)编码。GAD1基因位于人染色体2q31.1。GAD67位于树突和细胞体。

特異性

与 GAD67 特异性反应。不与 GAD65 发生交叉反应。

免疫原

来自小鼠 GAD67 的合成肽(氨基酸 87-106)。
该肽与 GAD65 不具有同源性。

應用

小鼠抗谷氨酸脱羧酶67(GAD67)单克隆抗体已被用于:
  • 免疫组织荧光
  • 蛋白质印迹
  • 免疫组织化学

抗谷氨酸脱羧酶 67(GAD67)单克隆抗体适用于免疫印迹、免疫印迹(1:500-1:20,000 稀释,小鼠脑提取物)和免疫组化(1:500-1:20,000 稀释,小鼠脑切片)。

生化/生理作用

谷氨酸脱羧酶67(GAD67)涉及 γ-氨基丁酸 (GABA)的生产,氨基丁酸是中枢神经系统 (CNS)中的一种抑制性神经递质。GAD67缺乏会导致精神病、精神分裂和双向情感障碍。

外觀

在含有 0.01% 叠氮化钠的磷酸盐缓冲盐水中的溶液。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

未找到適合的產品?  

試用我們的產品選擇工具.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Ying Chen et al.
Neuropharmacology, 60(7-8), 1075-1087 (2010-09-28)
GAD67 corresponds to one of two enzymes that decarboxylates glutamate to produce γ-aminobutyric acid, the main inhibitory neurotransmitter in the mammalian central nervous system, hence defining the cellular phenotype of a diverse set of inhibitory interneurons of the brain. Reduced
Minjung Kim et al.
PloS one, 7(2), e32043-e32043 (2012-03-01)
The analysis of co-localized protein expression in a tissue section is often conducted with immunofluorescence histochemical staining which is typically visualized in localized regions. On the other hand, chromogenic immunohistochemical staining, in general, is not suitable for the detection of
Mitsuhiro Tsuboi et al.
Cancer medicine, 8(9), 4189-4199 (2019-06-18)
In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with
A Guidotti et al.
Archives of general psychiatry, 57(11), 1061-1069 (2000-11-14)
Reelin (RELN) is a glycoprotein secreted preferentially by cortical gamma-aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin receptors located on dendritic spines of pyramidal neurons or on GABAergic interneurons of layers III through V expressing the
Baohu Ji et al.
PloS one, 8(6), e66327-e66327 (2013-07-05)
It has been well established that schizophrenia patients display impaired NMDA receptor (NMDAR) functions as well as exacerbation of symptoms in response to NMDAR antagonists. Abnormal NMDAR signaling presumably contributes to cognitive deficits which substantially contribute to functional disability in

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務