F9553

FTI-276 trifluoroacetate salt

≥95% (HPLC)

• 同義詞: N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
• 經驗公式（希爾表示法）: C₂₁H₂₇N₃O₃S₂ ·C₂HF₃O₂
• CAS號碼: 170006-72-1
• 分子量：: 547.61
• MDL號碼: MFCD06409253
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329799788
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: film
• 儲存條件: desiccated; under inert gas
• 顏色: off-white
• 溶解度: H₂O: >5 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• SMILES 字串: OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2)C(O)=O
• InChI: 1S/C21H27N3O3S2.C2HF3O2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27);(H,6,7)/t15-,19+;/m1./s1
• InChI 密鑰: IAVHISGQCODLHL-WSCVZUBPSA-N

描述

生化／生理作用

FTI-276 is a highly potent RasCAAX peptidomimetic.

FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC₅₀ of 500 pM and is an anti-cancer agent.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves