F0891

特戊酸氟米松

• 同義詞: 6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate), Flumetasone 21-pivalate, NSC 107680
• 經驗公式（希爾表示法）: C₂₇H₃₆F₂O₆
• CAS號碼: 2002-29-1
• 分子量：: 494.57
• EC號碼: 217-901-1
• MDL號碼: MFCD00079287
• 分類程式碼代碼: 51101500
• PubChem物質ID: 24894735
• NACRES: NA.85

屬性

• 形狀: solid
• 光學活性: [α]25/D 71.0 to 82.0°, c = 1 in dioxane
• 溶解度: dioxane: 4.0 mL, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)
• 作用方式: cell membrane | interferes
• SMILES 字串: [H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(=O)C(C)(C)C)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
• InChI: 1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1
• InChI 密鑰: JWRMHDSINXPDHB-OJAGFMMFSA-N
• 基因資訊: human ... NR3C1(2908)

描述

應用

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is used to study adrenocortical suppression, plasma transcortin binding, and cutaneous atrophy and telangiectasia.

生化／生理作用

Flumethasone pivalate is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activations and repressions. The anti-inflammatory action of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H351
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Carc. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges