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重要文件

來源證明/COA

EHU151981

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human HIF1A

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全部照片(1)

About This Item

分類程式碼代碼:

41105324

NACRES:

NA.51

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SIRNA

MISSION^® siRNA产品系列

OLIGO

定制DNA寡核苷酸

Sigma-Aldrich

637106

氧化铁(II,III)

SHRNA

MISSION^® shRNA Product Offerings

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SHCLND

MISSION^® shRNA

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CRISPR

CRISPR/Cas9产品及服务

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SHCLNV

MISSION^® shRNA

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EHU008751

MISSION^® esiRNA

GF41352791

银

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SIC001

MISSION^® siRNA通用阴性对照＃1

描述

品質等級

100

產品線

MISSION^®

形狀

lyophilized powder

esiRNA cDNA 標靶序列

TGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGC

Ensembl | 人類登錄號

ENSG00000100644

NCBI登錄號

NM_001530

運輸包裝

ambient

儲存溫度

−20°C

基因資訊

human ... HIF1A(3091) , HIF1A(3091)

一般說明

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法律資訊

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

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A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

Klaartje Somers et al.

Oncogene, 38(20), 3824-3842 (2019-01-24)

Survival rates for pediatric patients suffering from mixed lineage leukemia (MLL)-rearranged leukemia remain below 50% and more targeted, less toxic therapies are urgently needed. A screening method optimized to discover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a

Association Study of Genetic Variants in Autophagy Pathway and Risk of Non-syndromic Cleft Lip With or Without Cleft Palate.

Shu Lou et al.

Frontiers in cell and developmental biology, 8, 576-576 (2020-08-09)

Although genetic variants in autophagy pathway genes were associated with the risk of oral cancers and early development in embryos, their associations with non-syndromic cleft lip with or without cleft palate (NSCL/P) risk remained unclear. A two-stage case-control study (2,027

Study on the mechanism of HIF1a-SOX9 in glucose-induced cardiomyocyte hypertrophy.

Qianqian Gao et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 74, 57-62 (2015-09-10)

A major cause of morbidity and mortality in cardiovascular disease is pathological cardiac hypertrophy. With an increase in the cellular surface area and upregulation of the atrial natriuretic peptide (ANP) gene, cardiac hypertrophy is a prominent feature of diabetic cardiomyopathy.

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells.

Matilda Munksgaard Thorén et al.

Oncotarget, 8(30), 48983-48995 (2017-04-22)

We previously demonstrated that small cell lung carcinoma (SCLC) cells lack HIF-2α protein expression, whereas HIF-1α in these cells is expressed at both acute and prolonged hypoxia. Here we show that low HIF2A expression correlates with high expression of MYC

NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess.

Damir Kračun et al.

Redox biology, 34, 101536-101536 (2020-05-16)

Cardiovascular side effects are frequent problems accompanying systemic glucocorticoid therapy, although the underlying mechanisms are not fully resolved. Reactive oxygen species (ROS) have been shown to promote various cardiovascular diseases although the link between glucocorticoid and ROS signaling has been

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重要文件

MISSION^® esiRNA