E7528

Anti-S1P₅, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

• 同義詞: Anti-EDG-8, Anti-Endothelial Cell Differentiation Gene 8
• MDL號碼: MFCD03454973
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: fractionated antiserum
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~42 kDa by SDS-PAGE
• 物種活性: human
• 濃度: ~1 mg/mL
• 技術: western blot: suitable
• UniProt登錄號: Q9H228
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... S1PR5(53637)

描述

免疫原

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-8/S1P₅ receptor.

應用

Anti-S1P₅, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using RH7777 cells transfected with full length human EDG-8.

生化／生理作用

Sphingosine-1-phosphate receptor 5 (S1PR5) is a human gene which encodes a G protein-coupled receptor. It binds to lipid signaling molecule sphingosine 1-phosphate (S1P). S1PR5 regulates NK cell migration and distribution by interacting with sphingosine-1-phosphate (S1P). In brain endothelial cells (ECs), it contributes to optimal barrier formation and maintains immune quiescence of the barrier endothelium. S1PR5 is localized in the centrosome of mammalian cells and may participate in regulating mitosis. It may function as an intracellular target of S1P linked to regulation of mitosis.

外觀

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids