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About This Item
經驗公式（希爾表示法）:
C24H24 N4O2
CAS號碼:
分子量：:
400.47
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
化驗
>99.0% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
off-white to brown
溶解度
DMSO: 20 mg/mL
起源
Merck & Co., Inc., Kenilworth, NJ, U.S.
儲存溫度
2-8°C
SMILES 字串
C1CN(CCO1)CCOc2ccc(cc2)-c3cnc4c(cnn4c3)-c5ccccc5
InChI
1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
InChI 密鑰
SKZQZGSPYYHTQG-UHFFFAOYSA-N
生化／生理作用
DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.
特點和優勢
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
分析證明 (COA)
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文章
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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