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Merck
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文件

D4317

Sigma-Aldrich

3,5-Diiodothyropropionic acid

同義詞:

DITPA

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About This Item

經驗公式(希爾表示法):
C15H12I2O4
CAS號碼:
分子量::
510.06
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

儲存溫度

2-8°C

SMILES 字串

OC(=O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1

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生化/生理作用

DITPA, an analog of L-thyroxine, has inotropic but not chronotropic effects on heart muscle. It also stimulates myocardial angiogenesis after infarction by interaction with integrin αvཪ3 at the cell surface.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Abdelrahman A Abohashem-Aly et al.
The Journal of surgical research, 171(2), 379-385 (2011-06-11)
Thyroid hormone can have positive effects on the cardiovascular system but its therapeutic potential is limited secondary to its adverse effects. DITPA (3,5-diiodothyroproprionic acid) is a synthetic thyroid hormone analog with positive inotropic effects similar to thyroid hormone but with
Reza Arsanjani et al.
Journal of molecular and cellular cardiology, 51(4), 506-511 (2011-01-11)
Thyroid hormone has unique properties affecting the heart, and the vasculature and cholesterol metabolism. There is interest in using thyromimetic agents as possible treatment options for heart failure based on data demonstrating the ability of these agents to improve systolic
Peter H Spooner et al.
Journal of cardiovascular pharmacology, 44(4), 453-459 (2004-09-30)
This study was designed to determine if the thyroid hormone analog 3,5 diiodothyropropionic acid (DITPA), now in clinical trials for heart failure, alters endothelial function after myocardial infarction (MI). Three weeks after MI, adult Sprague-Dawley rats were randomly assigned to
Najah R Hadi et al.
BMC nephrology, 12, 70-70 (2011-12-27)
Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886
M A Hassan Talukder et al.
American journal of physiology. Heart and circulatory physiology, 300(2), H702-H711 (2010-12-07)
There is emerging evidence that treatment with thyroid hormone (TH) can improve postischemic cardiac function. 3,5-Diiodothyropropionic acid (DITPA), a TH analog, has been proposed to be a safer therapeutic agent than TH because of its negligible effects on cardiac metabolism

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