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D041

Sigma-Aldrich

S(+)-Propylnorapomorphine hydrochloride

solid

同義詞:

S(+)-NPA hydrochloride, S(+)10,11-Dihydroxy-N-n-propylnoraporphine hydrochloride

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About This Item

經驗公式(希爾表示法):
C19H21NO2 · HCl
CAS號碼:
分子量::
331.84
MDL號碼:
分類程式碼代碼:
12352210
PubChem物質ID:
NACRES:
NA.77

形狀

solid

品質等級

顏色

off-white

溶解度

H2O: moderately soluble
ethanol: soluble (Solutions should be freshly prepared.)

儲存溫度

2-8°C

SMILES 字串

Cl.[H][C@@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1CCC)c24

InChI

1S/C19H21NO2.ClH/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14;/h3-7,15,21-22H,2,8-11H2,1H3;1H/t15-;/m0./s1

InChI 密鑰

PCOQOGIDTIFQAM-RSAXXLAASA-N

一般說明

Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidant. Solutions should be freshly prepared.

生化/生理作用

Limbic-selective dopamine antagonist.

注意

Store tightly sealed at 4 °C; subject to rapid oxidation. Packed under argon; reseal bottle under argon or nitrogen to maximize stability.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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J L Neumeyer et al.
Journal of medicinal chemistry, 26(4), 516-521 (1983-04-01)
The enantiomers [(S)-(+) and (R)-(-)] of N-n-propylnorapomorphine (NPA) were synthesized. (R)-NPA was obtained by the acid-catalyzed rearrangement of N-n-propylnormorphine. (R)-NPA also was converted to (RS)-N-n-propylnorapomorphine dimethyl ether by dehydrogenation of the 10,11-O,O'-dimethyl ether of (R)-NPA with 10% palladium on carbon
R F Cox et al.
The Journal of pharmacology and experimental therapeutics, 247(1), 355-362 (1988-10-01)
Prompted by conflicting reports of both agonist and antagonist properties of the S-(+)-enantiomer of the potent dopamine agonist R-(-)-N-n-propylnorapomorphine (NPA), we carried out extracellular, single unit recording studies to compare the effects of both enantiomers on substantia nigra and ventral

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