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Merck
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重要文件

C9994

Sigma-Aldrich

CAMK2β, active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

同義詞:

CAM2, CAMKB, MG C29528

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

重組細胞

expressed in baculovirus infected Sf9 cells

品質等級

產品線

PRECISIO® Kinase

化驗

≥70% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

比活性

4820-6521 nmol/min·mg

分子量

~58 kDa

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... CAMK2B(816)

生化/生理作用

CAMK2β belongs to the serine/threonine protein kinase family and to the type II multifunctional Ca2+/calmodulin-dependent protein kinase subfamily. CAMK2β showed wide tissue and cell distribution, and one of CAMK2β variant predominated in adult brain. The ratio of CAMK2α and CAMK2β protein levels were inversely related during activity in hippocampal neurons. CAMK2β is a prominent kinase in the central nervous system and may function in long-term potentiation and neurotransmitter release.

外觀

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險聲明

危險分類

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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Tara C Thiagarajan et al.
Neuron, 36(6), 1103-1114 (2002-12-24)
We show that alpha and betaCaMKII are inversely regulated by activity in hippocampal neurons in culture: the alpha/beta ratio shifts toward alpha during increased activity and beta during decreased activity. The swing in ratio is approximately 5-fold and may help
R M Tombes et al.
Biochimica et biophysica acta, 1355(3), 281-292 (1997-03-01)
CaMK-II (the (type II) multifunctional Ca2+/CaM-dependent protein kinase) has been implicated in diverse neuronal and non-neuronal functions, including cell growth control. CaMKII expression was evaluated in a variety of human tumor cell lines using RT-PCR (reverse transcriptase coupled polymerase chain

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