C8990

Sp-8-pCPT-cAMPS

≥98% (HPLC), solid

• 同義詞: 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt
• 經驗公式（希爾表示法）: C₁₆H₁₄ClN₅O₅PS₂Na
• CAS號碼: 129693-13-6
• 分子量：: 509.86
• MDL號碼: MFCD04113743
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724452

屬性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 包裝: vial of 5 μmol
• 溶解度: H₂O: >1 mg/mL
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• SMILES 字串: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

描述

一般說明

Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP with a p-chlorophenylthio moiety.

應用

Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A. It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.

生化／生理作用

Selective cAMP-dependent protein kinase (PKA) activator.

Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition. It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination. It may play a role in lowering Leishmania proliferation in in vitro studies.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)