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C5490

Sigma-Aldrich

C75

≥98% (HPLC), powder

同義詞:

4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸

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About This Item

經驗公式(希爾表示法):
C14H22O4
CAS號碼:
分子量::
254.32
MDL號碼:
分類程式碼代碼:
41121801
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CCCCCCCCC1OC(=O)C(=C)C1C(O)=O

InChI

1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)

InChI 密鑰

VCWLZDVWHQVAJU-UHFFFAOYSA-N

應用

C75用于:
  • 作为脂肪酸合酶(FASN)抑制剂,测试其相较于二甲双胍,对FASN的直接抑制作用以及减弱乳腺球形成的能力
  • 作为抑制神经胶质瘤干细胞(GSC)中脂肪酸合成的药理抑制剂
  • 作为FAS 抑制剂 对Chang细胞进行预处理,以抑制脂肪生成并逆转过氧化氢诱导的衰老

生化/生理作用

C75有助于提高电离辐射的抗癌能力。
C75是一种新型、有效的脂肪酸合成酶(FAS)合成抑制剂,可用作研究代谢紊乱和癌症中脂肪酸合成的工具。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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存取文件庫

Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75
Rae C, et al.
Chirality, 29(1), 10-13 (2017)
Song-Hyo Jin et al.
PLoS neglected tropical diseases, 11(6), e0005687-e0005687 (2017-06-22)
Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in
Mauricio Rosas-Ballina et al.
Frontiers in immunology, 11, 131-131 (2020-03-07)
Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro-inflammatory activation of macrophages remains incompletely characterized. We show here
Cheulhee Jung et al.
Analytical and bioanalytical chemistry, 408(30), 8583-8591 (2016-04-02)
There are various ways that priming can occur in nucleic acid amplification reactions. While most reactions rely on a primer to initiate amplification, a mechanism for DNA amplification has been developed in which hairpin sequences at the 3' terminus of
Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b
Wahdan-Alaswad RS, et al.
Hormones & Cancer, 5(6), 374-389 (2014)

文章

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

脂肪酸合成有助於癌細胞增殖,對於膜生成、蛋白質修飾和生物能來說是不可或缺的。

Discover Bioactive Small Molecules for Lipid Signaling Research

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