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C5429

Sigma-Aldrich

Z-精氨酸-精氨酸-7-酰氨基-4-甲基香豆素 盐酸盐

同義詞:

Z-RR-AMC

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About This Item

經驗公式（希爾表示法）:
C30H39N9O6
CAS號碼:
136132-67-7
分子量：:
621.69
MDL號碼:
MFCD00133576
分類程式碼代碼:
12352209
PubChem物質ID:
24892784
NACRES:
NA.32

形狀

powder

品質等級

200

雜質

~4% isopropanol

儲存溫度

−20°C

SMILES 字串

Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

InChI

1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H

InChI 密鑰

HLSNWWKWVKPXKI-UHFFFAOYSA-N

基因資訊

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

Amino Acid Sequence

Z-Arg-Arg-AMC

應用

Z-精氨酸-精氨酸-7-氨基-4-甲基香豆素盐酸盐已用于：
  • 粪便提取物中蛋白酶酶谱分析中的组织蛋白酶B底物。
  • 组织蛋白酶B活性测定。
  • 作为荧光肽底物用于测定基质金属蛋白酶的活性。

基底

组织蛋白酶B的荧光底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number
BCCL5191
BCCJ3382
BCCF1094
BCCD5361
BCBV9324

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存取文件庫

High pressure effects on the activities of cathepsins B and D of mackerel and horse mackerel muscle
Fidalgo L G
Czech Journal of Food Sciences, 7, 53-53 (2014)
Kai S Beckwith et al.
Nature communications, 11(1), 2270-2270 (2020-05-10)
Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human monocytes and macrophages. A type VII secretion system (ESX-1)
Greta Geldenhuys et al.
Journal of the science of food and agriculture, 96(1), 271-279 (2015-02-03)
Baseline research on the toughness of Egyptian goose meat is required. This study therefore investigates the post mortem pH and temperature decline (15 min-4 h 15 min post mortem) in the pectoralis muscle (breast portion) of this gamebird species. It
Miguel G Ximénez-Embún et al.
PloS one, 11(1), e0145275-e0145275 (2016-01-07)
Climate change will bring more drought periods that will have an impact on the irrigation practices of some crops like tomato, from standard water regime to deficit irrigation. This will promote changes in plant metabolism and alter their interactions with
Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury
Cortes A L, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 102-114 (2018)
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文章

Enzymatic Assay of Cathepsin B

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

胰蛋白酶 B 的酵素分析

Cathepsin B 是一種具有廣泛特異性的溶酶體半胱氨酸蛋白酶。本方案使用 Nα-CBZ-Arg-Arg-7-amido-4-methylcoumarin 作為底物，以螢光計檢測 Cathepsin B 的活性。

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