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Key Documents

C3241

Sigma-Aldrich

Anti-CCR-7 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-C-C Chemokine Receptor 7

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

存貨情形

not available in Japan

濃度

~1 mg/mL

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

基因資訊

human ... CCR7(1236)
mouse ... Ccr7(12775)
rat ... Ccr7(287673)

免疫原

synthetic peptide corresponding to the C-terminal domain of human C-C chemokine receptor 7 (CCR7), conjugated to KLH.

生化/生理作用

CCR-7 is a G protein-coupled receptor that activates B and T lymphocytes. It mediates the effects of Epstein-Barr virus on B lymphocytes, regulates the migration of memory T cells to sites of inflammation and stimulates dendritic cell maturation.

外觀

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Praveen Akuthota et al.
American journal of respiratory cell and molecular biology, 48(6), 758-764 (2013-03-02)
Human eosinophils display directed chemotactic activity toward an array of soluble chemokines. Eosinophils have been observed to migrate to draining lymph nodes in experimental models of allergic inflammation, yet it is unknown whether eosinophils express CCR7, a key chemokine receptor
Karin Schaeuble et al.
Journal of cell science, 125(Pt 19), 4463-4474 (2012-07-17)
The chemokine receptor CCR7 is essential for lymphocyte and dendritic cell homing to secondary lymphoid organs. Owing to the ability to induce directional migration, CCR7 and its ligands CCL19 and CCL21 are pivotal for the regulation of the immune system.
Marc-André Allaire et al.
Immunology letters, 146(1-2), 70-73 (2012-06-05)
Prostaglandin E(2) (PGE(2)) induces the expression of C-C chemokine receptor type 7 (CCR7) on human monocytes, thereby enabling their subsequent migration in response to CCL19 and CCL21, the natural ligands for CCR7. To date, important mediators of PGE(2)-mediated monocyte migration

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