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C2741

Sigma-Aldrich

Anti-CCR-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-C-C Chemokine Receptor 1

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

存貨情形

not available in Japan

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL using human skeletal muscle, myocytes

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

基因資訊

human ... CCR1(1230)
mouse ... Ccr1(12768)
rat ... Ccr1(57301)

免疫原

synthetic peptide corresponding to the third extracellular loop of human C-C chemokine receptor 1 (CCR-1), conjugated to KLH. The immunizing peptide has 80% homology with the rat gene and 85% homology with the mouse gene.

生化/生理作用

CCR1 is a seven transmembrane protein that binds to macrophage inflammatory protein 1 alpha (MIP-1 alpha), monocyte chemoattractant protein 3 (MCP-3) and myeloid progenitor inhibitory factor-1 (MPIF-1). It has important role in protecting the host from inflammatory responses, viruses and parasites.

外觀

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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J Hesselgesser et al.
The Journal of biological chemistry, 273(25), 15687-15692 (1998-06-23)
The CC chemokines macrophage inflammatory protein-1alpha (MIP-1alpha) and RANTES (regulated on activation normal T cell expressed) have been implicated in rheumatoid arthritis and multiple sclerosis. Since their effects are mediated through the CCR1 chemokine receptor, we set up a small

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