生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~28 kDa
物種活性
human
技術
western blot: 1:500-1:2,000
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CLIC2(1193)
一般說明
Chloride intracellular channel protein 2 is a protein encoded by the CLIC2 gene in humans and belongs to chloride intracellular channel (CLIC) family. It is also referred as CLIC2b, MRXS32 and XAP121. CLIC2 protein is a member of the glutathione transferase class of proteins and they can exist as integral membrane-channel form or a soluble form. The gene is possibly associated with one of the many diseases linked to Xq28.
免疫原
synthetic peptide corresponding to amino acids 233-247 of human CLIC2
應用
Anti-CLIC2 (233-247) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生化／生理作用
Chloride intracellular channel 2 (CLIC2) functions by regulating ryanodine receptor (RyR) intracellular Ca(2+) release channels. RyR proteins play a major role in the regulation of Ca(2+) signaling in many cells. CLIC2 protein also helps in maintaining normal cognitive function by interacting with RyRs in the brain. In healthy individuals it is studied that the CLIC2 protein can tolerate amino acid substitutions and can be fully functional.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Not finding the right product?
Try our 產品選擇工具.
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Kyoko Takano et al.
Human molecular genetics, 21(20), 4497-4507 (2012-07-21)
Chloride intracellular channel 2 (CLIC2) protein is a member of the glutathione transferase class of proteins. Its' only known function is the regulation of ryanodine receptor (RyR) intracellular Ca(2+) release channels. These RyR proteins play a major role in the
N S Heiss et al.
Genomics, 45(1), 224-228 (1997-10-27)
A transcript map was previously constructed in the 1200-kb telomeric region of Xq28. One of the cDNAs, XAP121, displayed homology to a p64 bovine chloride channel and to a human chloride channel (p64CLCP, NCC27) at both the nucleotide and the
Brett A Cromer et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 63(Pt 11), 961-963 (2007-11-17)
The chloride intracellular channel (CLIC) family of proteins are unusual in that they can exist in either an integral membrane-channel form or a soluble form. Here, the expression, purification, crystallization and preliminary diffraction analysis of CLIC2, one of the least-studied
Shawn Witham et al.
Proteins, 79(8), 2444-2454 (2011-06-02)
Large-scale next generation resequencing of X chromosome genes identified a missense mutation in the CLIC2 gene on Xq28 in a male with X-linked intellectual disability (XLID) and not found in healthy individuals. At the same time, numerous nsSNPs (nonsynonomous SNP)
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務