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Merck
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重要文件

C0610

Sigma-Aldrich

8-Chloroadenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer

≥99% (HPLC)

同義詞:

Rp-8-Cl-cAMPS

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About This Item

經驗公式(希爾表示法):
C10H10ClN5O5PSNa
CAS號碼:
分子量::
401.70
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥99% (HPLC)

形狀

solid

包裝

vial of 5 μmol

儲存溫度

−20°C

SMILES 字串

Nc1ncnc2n([C@@H]3O[C@@H]4CO[P@@](S)(=O)O[C@H]4[C@H]3O)c(Cl)nc12

InChI

1S/C10H11ClN5O5PS/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(20-9)1-19-22(18,23)21-6/h2-3,5-6,9,17H,1H2,(H,18,23)(H2,12,13,14)/t3-,5-,6-,9-,22-/m1/s1

InChI 密鑰

PJAHPRNGOHUYQD-KVBUDSETSA-N

生化/生理作用

Competitive inhibitor of cyclic AMP-dependent protein kinase A (PKA) type I. Membrane-permeable analog of the cAMP inhibitor Rp-cAMPS (Prod. No. A-165).

特點和優勢

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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H Yokozaki et al.
Cancer research, 52(9), 2504-2508 (1992-05-01)
A set of adenosine 3':5'-monophosphate (cAMP) analogues that combine exocyclic sulfur substitutions in the equatorial (Rp) or the axial (Sp) position of the cyclophosphate ring with modifications in the adenine base of cAMP were tested for their effect on the
Ibtesam Almami et al.
British journal of pharmacology, 171(16), 3946-3960 (2014-05-14)
Tissue transglutaminase (TG2) has been shown to mediate cell survival in many cell types. In this study, we investigated whether the role of TG2 in cytoprotection was mediated by the activation of PKA and PKC in cardiomyocyte-like H9c2 cells. H9c2

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