化驗
≥97% (HPLC)
形狀
solid
儲存條件
under inert gas
顏色
yellow
溶解度
DMSO: ~10 mg/mL
儲存溫度
2-8°C
SMILES 字串
COc1ccc2nc3cc(Cl)ccc3c(NCCCN4CCN(CCCNc5c6ccc(Cl)cc6nc7ccc(OC)cc57)CC4)c2c1
InChI
1S/C38H40Cl2N6O2/c1-47-27-7-11-33-31(23-27)37(29-9-5-25(39)21-35(29)43-33)41-13-3-15-45-17-19-46(20-18-45)16-4-14-42-38-30-10-6-26(40)22-36(30)44-34-12-8-28(48-2)24-32(34)38/h5-12,21-24H,3-4,13-20H2,1-2H3,(H,41,43)(H,42,44)
InChI 密鑰
GUTKNTSGEOMFPZ-UHFFFAOYSA-N
生化／生理作用
Inhibitor of the formation of abnormal ß-rich isoform of prion protein PrPSc.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Barnaby C H May et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(6), 3416-3421 (2003-03-11)
Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency
Christopher A Ross et al.
Nature medicine, 10 Suppl, S10-S17 (2004-07-24)
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates
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