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Merck
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文件

B7272

Sigma-Aldrich

4-溴钙离子载体A23187

powder

同義詞:

4-溴-A23187, 4-溴-钙霉素

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About This Item

經驗公式（希爾表示法）:
C29H36BrN3O6
CAS號碼:
76455-48-6
分子量：:
602.52
MDL號碼:
MFCD00077667
分類程式碼代碼:
12352202
PubChem物質ID:
24891982
NACRES:
NA.77

形狀

powder

品質等級

200

顏色

yellow

溶解度

ethanol: 20 mg/mL
DMSO: soluble

儲存溫度

2-8°C

SMILES 字串

CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O

InChI

1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1

InChI 密鑰

LDXQFZZGVTWFCF-FHYGWRBKSA-N

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應用

4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
非荧光Ca2+离子载体，可用于通过荧光探针校准细胞质游离Ca2+的定量。

生化／生理作用

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.

其他說明

Analog of calcium ionophore A23187

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析證明 (COA)

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Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.
Whyte MK, et al.
The Journal of Clinical Investigation, 92(1), 446-455 (1993)
Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons.
Kim HJ, et al.
Experimental & Molecular Medicine, 39(5), 574-574 (2007)
Kinetics of endogenous CaMKII required for synaptic plasticity revealed by optogenetic kinase inhibitor.
Murakoshi H, et al.
Neuron, 94(1), 37-47 (2017)
G A Lnenicka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(13), 4966-4972 (1998-06-23)
In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2+ ionophore application, normally active tonic motor axons continue to grow, whereas
R Martínez-Zaguilán et al.
Journal of cellular physiology, 176(1), 196-205 (1998-06-09)
We investigated whether alterations in the mechanisms involved in intracellular pH (pHin) and intracellular calcium ([Ca2+]in) homeostasis are associated with the metastatic potential of poorly (A375P) and highly (C8161) metastatic human melanoma cells. We monitored pHin and [Ca2+]in simultaneously, using
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