B3811

B-9430 trifluoroacetate salt

≥98% (HPLC)

• 同義詞: D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp³, Igl⁵, D-Igl⁷, Oic⁸]-Bradykinin trifluoroacetate salt
• 經驗公式（希爾表示法）: C₆₄H₉₅N₁₉O₁₃ · xC₂HF₃O₂
• CAS號碼: 180981-09-3
• 分子量：: 1338.56 (free base basis)
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: protect from light; under inert gas
• 溶解度: H₂O: ≥2 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C

描述

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

生化／生理作用

B-9430 was developed by Gera at the Stewart laboratory¹ and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA₂ = 8.6) and B1 receptors (pA₂ = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

Stable, potent, and long lasting Bradykinin (BK) antagonist, which shows high BK antagonism on both B-1 and B-2 receptors.

注意

Product is air and light sensitive. Store in the dark.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable