B1061

BN82002 hydrochloride

≥97% (HPLC), solid

• 同義詞: 4-Dimethylamino-2-methoxy-6-((methyl-[2-(4-nitrophenyl)ethyl]amino)methyl)phenol
• 經驗公式（希爾表示法）: C₁₉H₂₅N₃O₄ · xHCl
• CAS號碼: 396073-89-5
• 分子量：: 359.42 (free base basis)
• MDL號碼: MFCD08276984
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724410

屬性

• 化驗: ≥97% (HPLC)
• 形狀: solid
• 顏色: tan
• 溶解度: DMSO: 10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].COc1cc(cc(CN(C)CCc2ccc(cc2)[N+]([O-])=O)c1O)N(C)C

描述

生化／生理作用

BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor.

BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase (IC₅₀ in μM = 2.4, 3.9, 6.3, 5.4, and 4.6 for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 has been shown to delay cell cycle progression in vitro (IC₅₀ in the range of 7.2 - 32.6 μM). BN82002 reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).

注意

Hygroscopic.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)